Regorafenib monohydrate
Product Specifications
CAS Number
1019206-88-2
Target
C-Kit|||PDGFR|||Tie-2|||Autophagy|||Raf|||FGFR|||c-RET|||VEGFR
Related Pathways
MAPK|||Apoptosis|||Tyrosine Kinase/Adaptors|||Angiogenesis|||Autophagy
Purity
0.9969
Bioactivity
Regorafenib Monohydrate is a novel oral multikinase inhibitor with IC50 values of 13, 4.2, 46, 22, 7, 1.5, 2.5, 28, 19 nM for VEGFR1, murine VEGFR2, murine VEGFR3, PDGFR-?, KIT, RET, RAF-1, B-RAF and B-RAF (V600E) respectively.
Smiles
O.CNC(=O)c1cc(Oc2ccc(NC(=O)Nc3ccc(Cl)c(c3)C(F)(F)F)c(F)c2)ccn1
Molecular Formula
C21H17ClF4N4O4
Molecular Weight
500.83
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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