Ceritinib dihydrochloride
Product Specifications
CAS Number
1380575-43-8
Target
ALK, IGF-1R
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9999
Bioactivity
Ceritinib dihydrochloride (LDK378 dihydrochloride) is a selective, orally bioavailable, ATP-competitive inhibitor of ALK tyrosine kinase (IC50 of 200 pM) and also inhibits IGF-1R, InsR, and STK22D [IC50 values of 8, 7, and 23 nM, respectively], demonstrating significant antitumor potency.
Smiles
Cl.Cl.CC(C)Oc1cc(C2CCNCC2)c(C)cc1Nc1ncc(Cl)c(Nc2ccccc2S(=O)(=O)C(C)C)n1
Molecular Formula
C28H38Cl3N5O3S
Molecular Weight
631.06
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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