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SU4984

SU4984 is a protein tyrosine kinase inhibitor, with an IC50 of 10-20 μM for fibroblast growth factor receptor 1 (FGFR1) . SU4984 is also inhibits platelet-derived growth factor receptor, and insulin receptor. SU4984 can be used for the research of cancer[1][2][3].

Product Specifications

CAS Number

[186610-89-9]

UNSPSC

12352005

Target

FGFR; Insulin Receptor; PDGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/su4984.html

Purity

99.70

Solubility

DMSO : 50 mg/mL (ultrasonic)

Smiles

O=CN1CCN(CC1)C2=CC=C(C=C2)/C=C3C(NC4=C\3C=CC=C4)=O

Molecular Formula

C20H19N3O2

Molecular Weight

333.38

References & Citations

[1]Mohammadi M, et, al. Structures of the tyrosine kinase domain of fibroblast growth factor receptor in complex with inhibitors. Science. 1997 May 9;276 (5314) :955-60.|[2]Ma Y, et, al. Indolinone derivatives inhibit constitutively activated KIT mutants and kill neoplastic mast cells. J Invest Dermatol. 2000 Feb;114 (2) :392-4.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, protect from light)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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