Nintedanib
Product Specifications
CAS Number
656247-17-5
Target
PDGFR, FLT, VEGFR, FGFR, Src
Related Pathways
Tyrosine Kinase/Adaptors, Angiogenesis
Purity
0.9992
Bioactivity
Nintedanib (Intedanib) is a triple vascular kinase inhibitor that inhibits VEGFR1, VEGFR2, and VEGFR3 (IC50=34/13/13 nM), FGFR1, FGFR2, and FGFR3 (IC50=69/37/108 nM), PDGFRα, and PDGFRβ (IC50=59/65 nM) . Nintedanib has antitumor activity and inhibits tumor growth by inhibiting angiogenesis.
Smiles
COC(c1cc2c(/C(C(N2)=O)=C(c3ccccc3)/Nc4ccc(N(C(CN5CCN(CC5)C)=O)C)cc4)cc1)=O
Molecular Formula
C31H33N5O4
Molecular Weight
539.62
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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