CL2 Linker
Product Specifications
CAS Number
2270986-66-6
Target
ADC Linker
Related Pathways
Antibody-drug Conjugate/ADC Related
Bioactivity
CL2 Linker is a cleavableADC linker. CL2-SN-38 and CL2A-SN-38 are equivalent in drug substitution (~6), cell binding (Kd ~1.2 nM), cytotoxicity (IC50 ~2.2 nM), and serum stability in vitro (t1/2 ~20 hours) [1][2].
Smiles
[C@H](CC1=CC=CC=C1)(C(N[C@H](C(NC2=CC=C(COC(N(CCN(C(OCC(CO)=O)=O)C)C)=O)C=C2)=O)CCCCNC(OC(C)(C)C)=O)=O)NC(CCOCCOCCOCCOCCOCCOCCOCCOCCN3C=C(CNC(CCCCCN4C(=O)C=CC4=O)=O)N=N3)=O
Molecular Formula
C68H103N11O22
Molecular Weight
1426.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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