AmPEG6C2-Aur0131

AmPEG6C2-Aur0131 is a drug-linker conjugate designed for anti-CXCR4 ADC applications, showcasing potent antitumor activity. It incorporates Aur0131, an auristatin-based microtubule inhibitor, connected through the non-cleavable AmPEG6C2 linker.

[C@H]([C@H](C(N[C@@H](CC1=CC=CC=C1)C(O)=O)=O)C)(OC)[C@]2(N(C(C[C@H]([C@@H](N(C([C@@H](NC(=O)[C@@]3(C)N(C(CCOCCOCCOCCOCCOCCOCCN)=O)CCC3)C(C)C)=O)C)[C@H](CC)C)OC)=O)CCC2)[H]