ACBI1
Product Specifications
CAS Number
2375564-55-7
Target
Apoptosis, Epigenetic Reader Domain, PROTACs
Related Pathways
Chromatin/Epigenetic, Apoptosis, PROTAC
Purity
0.9815
Bioactivity
ACBI1 is a potent PROTAC degrader of BAF ATPase subunits SMARCA2 and SMARCA4, also degrades the polybromo-associated BAF (PBAF) complex member PBRM1, with DC50s of 6 nM, 11 nM and 32 nM for SMARCA2, SMARCA4 and PBRM1 in MV-4-11 cells, respectively. ACBI1 is composed of a bromodomain ligand, a linker, and the E3 ubiquitin ligase VHL. ACBI1 can induce anti-proliferative effects and apoptosis.
Smiles
NC1=C(C=C(N=N1)C2=C(O)C=CC=C2)N3CCN(CC4=CC=C(OCCOC5=C(CNC(=O)[C@H]6N(C([C@@H](NC(=O)C7(F)CC7)C(C)(C)C)=O)C[C@H](O)C6)C=CC(=C5)C8=C(C)N=CS8)C=C4)CC3
Molecular Formula
C49H58FN9O7S
Molecular Weight
936.1
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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