Human VEGF-C (Recombinant and Highly Pure)

<strong>Human VEGF-C (Highly Pure)</strong>_x000D_ <strong>Catalog number:</strong> B2010374_x000D_ <strong>Lot number:</strong> Batch Dependent_x000D_ <strong>Expiration Date:</strong> Batch dependent_x000D_ <strong>Volume/Weight:</strong> 10 ug_x000D_ <strong>pH:</strong> 7.4 upon reconstitution_x000D_ <strong>Supplied as:</strong> Lyophilized Powder_x000D_ <strong>Appearance:</strong> Powder_x000D_ <strong>Applications:</strong> highly pure Human VEGF-C (Highly Pure) expressed in HEK 293. This protein acts as a protein involved in lymphangiogenesis whereby it acts on lymphatic endothelial cells (LECs) primarily via its receptor VEGFR-3 promoting survival, growth and migration._x000D_ <strong>Storage:</strong> -20C_x000D_ <strong>Keywords:</strong> rHuVEGF-C; Vascular endothelial growth factor C; Flt4-L; VRP_x000D_ <strong>Grade:</strong> Biotechnology grade. All components are highly pure (minimum 95%). All solutions are made with Type I ultrapure water (resistivity &gt;18 MΩ-cm) and are filtered through 0.22 um._x000D_ _x000D_ <strong>References:</strong>_x000D_ 1: Song E, Mao T, Dong H, Boisserand LSB, Antila S, Bosenberg M, Alitalo K,_x000D_ Thomas JL, Iwasaki A. VEGF-C-driven lymphatic drainage enables_x000D_ immunosurveillance of brain tumours. Nature. 2020 Jan;577(7792):689-694._x000D_ _x000D_ 2: Su CM, Tang CH, Chi MJ, Lin CY, Fong YC, Liu YC, Chen WC, Wang SW. Resistin_x000D_ facilitates VEGF-C-associated lymphangiogenesis by inhibiting miR-186 in human_x000D_ chondrosarcoma cells. Biochem Pharmacol. 2018 Aug;154:234-242._x000D_ _x000D_ 3: Li WN, Hsiao KY, Wang CA, Chang N, Hsu PL, Sun CH, Wu SR, Wu MH, Tsai SJ._x000D_ Extracellular vesicle-associated VEGF-C promotes lymphangiogenesis and immune_x000D_ cells infiltration in endometriosis. Proc Natl Acad Sci U S A. 2020 Oct_x000D_ 13;117(41):25859-25868._x000D_ _x000D_ 4: Schwager S, Detmar M. Inflammation and Lymphatic Function. Front Immunol._x000D_ 2019 Feb 26;10:308._x000D_ _x000D_ 5: Cheng MX, Li JZ, Chen Y, Cao D, Gong JP, Tu B. VEGF-C attenuates ischemia_x000D_ reperfusion injury of liver graft in rats. Transpl Immunol. 2019 Jun;54:59-64._x000D_ _x000D_ 6: Yang ZS, Xu YF, Huang FF, Ding GF. Associations of nm23H1, VEGF-C, and VEGF-3_x000D_ receptor in human prostate cancer. Molecules. 2014 May 23;19(5):6851-62._x000D_ _x000D_ 7: Miao H, Ruan S, Shen M. VEGF-C in rectal cancer tissues promotes tumor_x000D_ invasion and metastasis. J BUON. 2018 Jan-Feb;23(1):42-47._x000D_ _x000D_ 8: Wang LH, Lin CY, Liu SC, Liu GT, Chen YL, Chen JJ, Chan CH, Lin TY, Chen CK,_x000D_ Xu GH, Chen SS, Tang CH, Wang SW. CCL5 promotes VEGF-C production and induces_x000D_ lymphangiogenesis by suppressing miR-507 in human chondrosarcoma cells._x000D_ Oncotarget. 2016 Jun 14;7(24):36896-36908._x000D_ <a href="https://pubmed.ncbi.nlm.nih.gov/29939339/">9: Michaelsen SR, Staberg M, Pedersen H, Jensen KE, Majewski W, Broholm H,_x000D_ Nedergaard MK, Meulengracht C, Urup T, Villingshøj M, Lukacova S, Skjøth-_x000D_ Rasmussen J, Brennum J, Kjær A, Lassen U, Stockhausen MT, Poulsen HS, Hamerlik_x000D_ P. VEGF-C sustains VEGFR2 activation under bevacizumab therapy and promotes_x000D_ glioblastoma maintenance. Neuro Oncol. 2018 Oct 9;20(11):1462-1474. </a>_x000D_ _x000D_ <strong>Products Related to Human VEGF-C (Highly Pure) </strong> <a href="https://moleculardepot.com/product-category/Proteins/">: Proteins</a>