VU0463271
Product Specifications
CAS Number
1391737-01-1
Target
Potassium Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.9975
Bioactivity
VU0463271 (N-Cyclopropyl-N- (4-methyl-2-thiazolyl) -2-[ (6-phenyl-3-pyridazinyl) thio]acetamide) is a potent and selective antagonist of the neuronal-specific potassium-chloride cotransporter 2 (KCC2), with an IC50 of 61 nM and >100-fold selectivity versus the closely related Na-K-2Cl cotransporter 1 (NKCC1) and no activity in a larger panel of GPCRs, ion channels, and transporters.
Smiles
Cc1csc(n1)N(C1CC1)C(=O)CSc1ccc(nn1)-c1ccccc1
Molecular Formula
C19H18N4OS2
Molecular Weight
382.5
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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