3-Chloro-L-tyrosine

3-Chloro-L-tyrosine is a specific biomarker in myeloperoxidase-catalyzed oxidation. 3-Chloro-L-tyrosine can be used as a molecular marker for oxidative stress and inflammation to determine whether myeloperoxidase-mediated tyrosine chlorination occurs. 3-Chloro-L-tyrosine is therefore used in the diagnosis of chlorine poisoning in forensic toxicology and in the auxiliary diagnosis of inflammation such as colorectal cancer[1][2].

Product Specifications

CAS Number

[7423-93-0]

Product Name Alternative

3-Chlorotyrosine

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Glutathione Peroxidase

Type

Natural Products

Related Pathways

Apoptosis; Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Others

Assay Protocol

https://www.medchemexpress.com/3-Cl-Tyr-OH.html

Concentration

10mM

Purity

98.13

Solubility

DMSO : < 1 mg/mL (ultrasonic; warming; heat to 60°C) |H2O : 5 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)[C@@H](N)CC1=CC=C(O)C(Cl)=C1

Molecular Formula

C9H10ClNO3

Molecular Weight

215.64

Precautions

H302, H315, H319, H335

References & Citations

[1]Nishio T, et al. Determination of 3-chloro-l-tyrosine as a novel indicator of chlorine poisoning utilizing gas chromatography-mass spectrometric analysis. Leg Med (Tokyo) . 2020 Nov;47:101782.|[2]Fleszar MG, et al. Simultaneous LC-MS/MS-Based Quantification of Free 3-Nitro-l-tyrosine, 3-Chloro-l-tyrosine, and 3-Bromo-l-tyrosine in Plasma of Colorectal Cancer Patients during Early Postoperative Period. Molecules. 2020 Nov 5;25 (21) :5158.