Bufalin
Product Specifications
CAS Number
465-21-4
Target
ATPase
Related Pathways
Membrane transporter/Ion channel
Purity
0.998
Bioactivity
Bufalin is an active ingredient and one of the glycosides in the traditional Chinese medicine ChanSu; it is also a bufadienolide toxin originally isolated from the venom of the Chinese toad Bufo gargarizans, with potential cardiotonic and antineoplastic activity. Although the mechanism of action of bufalin is still under investigation, this agent is a specific Na+/K+-ATPase inhibitor and can induce apoptosis in Y cell lines through the activation of the transcription factor AP-1 via a mitogen activated protein kinase (MAPK) pathway.
Smiles
[H][C@]12CC[C@]3([H])[C@]([H])(CC[C@]4(C)[C@H](CC[C@]34O)c3ccc(=O)oc3)[C@@]1(C)CC[C@H](O)C2
Molecular Formula
C24H34O4
Molecular Weight
386.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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