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TX1-85-1

Product Specifications

CAS Number

1603845-32-4

Target

EGFR

Related Pathways

Tyrosine Kinase/Adaptors, Angiogenesis, JAK/STAT signaling

Purity

0.9812

Bioactivity

TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM) . TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.

Smiles

CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12

Molecular Formula

C32H36N8O3

Molecular Weight

580.68

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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