TX1-85-1
Product Specifications
CAS Number
1603845-32-4
Target
EGFR
Related Pathways
Tyrosine Kinase/Adaptors|||Angiogenesis|||JAK/STAT signaling
Purity
0.9812
Bioactivity
TX1-85-1 induces partial degradation of Her3 protein and attenuates Her3-dependent signaling. TX1-85-1 is an irreversible Her3 inhibitor (IC50: 23 nM) . TX1-85-1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP-binding site of Her3.
Smiles
CC(=O)N1CCN(CC1)C1CCC(CC1)n1nc(-c2ccc(Oc3ccccc3)c(NC(=O)C=C)c2)c2c(N)ncnc12
Molecular Formula
C32H36N8O3
Molecular Weight
580.68
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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