Tos-PEG4-t-butyl ester
Product Specifications
CAS Number
217817-01-1
Target
Others|||PROTAC Linker
Related Pathways
PROTAC|||Others
Bioactivity
Tos-PEG4-t-butyl ester (Tos-PEG4-Boc) is a PROTAC linker characterized by its PEG composition, crucial in synthesizing various PROTACs, including BI-3663, a selective PTK2/FAK PROTAC. Using cereblon ligands, it targets E3 ligases to degrade PTK2, exhibiting potent inhibitory activity with an IC50 of 18 nM[1].
Smiles
S(OCCOCCOCCOCCC(OC(C)(C)C)=O)(=O)(=O)C1=CC=C(C)C=C1
Molecular Formula
C20H32O8S
Molecular Weight
432.53
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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