Boc-Val-Ala-PAB-PNP
Boc-Val-Ala-PAB-PNP is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1].
Product Specifications
CAS Number
1884578-00-0
UNSPSC
12352203
Hazard Statement
H315, H319
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/boc-val-ala-pab-pnp.html
Purity
98.77
Solubility
DMSO : 35 mg/mL (ultrasonic)
Smiles
CC([C@H](NC(OC(C)(C)C)=O)C(N[C@H](C(NC1=CC=C(C=C1)COC(OC2=CC=C(C=C2)[N+]([O-])=O)=O)=O)C)=O)C
Molecular Formula
C27H34N4O9
Molecular Weight
558.58
Precautions
H315, H319
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker; Protease Cleavable Linker
Available Sizes
Frequently Asked Questions
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