SN-38
Product Specifications
CAS Number
86639-52-3
Target
ADC Cytotoxin, Autophagy, Drug Metabolite, DNA/RNA Synthesis, Topoisomerase
Related Pathways
Autophagy, Metabolism, Antibody-drug Conjugate/ADC Related, DNA Damage/DNA Repair, Cell Cycle/Checkpoint
Purity
0.9997
Bioactivity
SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM) . SN-38 has antitumor activity and induces autophagy.
Smiles
C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5
Molecular Formula
C22H20N2O5
Molecular Weight
392.4
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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