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SN-38

Product Specifications

CAS Number

86639-52-3

Target

ADC Cytotoxin, Autophagy, Drug Metabolite, DNA/RNA Synthesis, Topoisomerase

Related Pathways

Autophagy, Metabolism, Antibody-drug Conjugate/ADC Related, DNA Damage/DNA Repair, Cell Cycle/Checkpoint

Purity

0.9997

Bioactivity

SN-38 (NK012) is the active metabolite of Irinotecan, a DNA topoisomerase I (Topo I) inhibitor, which inhibits DNA and RNA synthesis (IC50=0.077/1.3 μM) . SN-38 has antitumor activity and induces autophagy.

Smiles

C(C)C1=C2C(C=3N(C2)C(=O)C4=C(C3)[C@](CC)(O)C(=O)OC4)=NC=5C1=CC(O)=CC5

Molecular Formula

C22H20N2O5

Molecular Weight

392.4

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

Frequently Asked Questions

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