Tefinostat
Product Specifications
CAS Number
914382-60-8
Target
Apoptosis, HDAC
Related Pathways
Chromatin/Epigenetic, Apoptosis, DNA Damage/DNA Repair
Purity
0.9983
Bioactivity
Tefinostat (CHR-2845) is a potent monocyte/macrophage-targeted histone deacetylase (HDAC) inhibitor that is cleaved to the active acid CHR-2847 by intracellular esterase human carboxylesterase-1 (hCE-1) . Tefinostat exhibits antitumor activity and can be used in the study of leukemia and advanced hematologic malignancies.
Smiles
ONC(=O)CCCCCCC(=O)Nc1ccc(CN[C@H](C(=O)OC2CCCC2)c2ccccc2)cc1
Molecular Formula
C28H37N3O5
Molecular Weight
495.61
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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