TC-S 7009
Product Specifications
CAS Number
1422955-31-4
Target
HIF/HIF Prolyl-Hydroxylase, HIF
Related Pathways
Chromatin/Epigenetic, Angiogenesis, Metabolism
Purity
>99.99%
Bioactivity
TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM) with significantly higher affinity for HIF-2α than HIF-1α (Kd >> 5μM) . TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene expression, and diminishes DNA binding activity.
Smiles
[O-][N+](=O)c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12
Molecular Formula
C12H6ClFN4O3
Molecular Weight
308.65
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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