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TC-S 7009

Product Specifications

CAS Number

1422955-31-4

Target

HIF/HIF Prolyl-Hydroxylase, HIF

Related Pathways

Chromatin/Epigenetic, Angiogenesis, Metabolism

Purity

>99.99%

Bioactivity

TC-S 7009 is a potent and selective HIF-2α inhibitor (Kd: 81 nM) with significantly higher affinity for HIF-2α than HIF-1α (Kd >> 5μM) . TC-S 7009 disrupts HIF-2α heterodimerization, reduces HIF-2α target gene expression, and diminishes DNA binding activity.

Smiles

[O-][N+](=O)c1c(Nc2cc(F)cc(Cl)c2)ccc2nonc12

Molecular Formula

C12H6ClFN4O3

Molecular Weight

308.65

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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