Tazemetostat hydrobromide
Product Specifications
CAS Number
1467052-75-0
Target
Histone Methyltransferase
Related Pathways
Chromatin/Epigenetic
Purity
0.998
Bioactivity
Tazemetostat hydrobromide (E-7438 hydrobromide) is a potent and selective EZH2 inhibitor. Tazemetostat hydrobromide inhibits the activity of human polycomb repressive complex 2 (PRC2) -containing wild-type EZH2 (Ki: 2.5 nM) . Tazemetostat hydrobromide also inhibits EZH1 (IC50: 392 nM) .
Smiles
O=C(C1=CC(C2=CC=C(CN3CCOCC3)C=C2)=CC(N(CC)C4CCOCC4)=C1C)NCC5=C(C)C=C(C)NC5=O.[H]Br
Molecular Formula
C34H45BrN4O4
Molecular Weight
653.65
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
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