TAS6417

Product Specifications

CAS Number

1661854-97-2

Target

Apoptosis, EGFR

Related Pathways

Tyrosine Kinase/Adaptors, JAK/STAT signaling, Angiogenesis, Apoptosis

Purity

0.9971

Bioactivity

Zipalertinib (TAS6417, CLN-081) is a novel, highly potent, orally active covalent EGFR tyrosine kinase inhibitor that uniquely binds to the ATP binding site of the EGFR hinge region with an IC50 value of 1.1-8.0 nM.

Smiles

CC1=C[C@@H](Cn2c1c(-c1cnc3ccccc3c1)c1c(N)ncnc21)NC(=O)C=C

Molecular Formula

C23H20N6O

Molecular Weight

396.44

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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