TAK-243
Product Specifications
CAS Number
1450833-55-2
Target
NF-κB, Apoptosis, E1/E2/E3 Enzyme
Related Pathways
Apoptosis, NF-κB, Ubiquitination
Purity
0.9893
Bioactivity
TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis.
Smiles
NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O
Molecular Formula
C19H20F3N5O5S2
Molecular Weight
519.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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