(S, R, S) -AHPC-C1-NH2 (hydrochloride)

(S, R, S) -AHPC-C1-NH2 hydrochloride is a synthesized E3 ligase ligand-linker conjugate that incorporates the (S, R, S) -AHPC based VHL ligand and a linker used in PROTAC technology[1].

Product Specifications

CAS Number

[2361120-26-3]

UNSPSC

12352005

Hazard Statement

H302, H315, H319

Target

E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/s-r-s-ahpc-c1-nh2-hydrochloride.html

Purity

98.08

Solubility

DMSO : 125 mg/mL (ultrasonic)

Smiles

NCC(N[C@@H](C(C)(C)C)C(N1[C@@H](C[C@H](C1)O)C(NCC2=CC=C(C3=C(N=CS3)C)C=C2)=O)=O)=O.[H]Cl

Molecular Formula

C24H34ClN5O4S

Molecular Weight

524.08

Precautions

H302, H315, H319

References & Citations

[1]Scheepstra M, et al. Bivalent Ligands for Protein Degradation in Drug Discovery. Comput Struct Biotechnol J. 2019;17:160-176. Published 2019 Jan 25.|[2]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-985.