Ralimetinib
Product Specifications
CAS Number
862505-00-8
Target
Others, Autophagy, MAPK, p38 MAPK
Related Pathways
Others, MAPK, Autophagy
Purity
0.9921
Bioactivity
Ralimetinib is a selective inhibitor that blocks phosphorylation of MK2 at Thr334, without affecting the phosphorylation of p38α MAPK, JNK, ERK1/2, c-Jun, ATF2, or c-Myc. Ralimetinib functions as an ATP-competitive inhibitor of p38 MAPK α/β, demonstrating IC50 values of 5.3 and 3.2 nM, respectively, and is under investigation as an anti-inflammatory and anticancer therapeutic.
Smiles
FC=1C=CC(=CC1)C=2N=C(NC2C3=NC4=C(N=C(N)N4CC(C)(C)C)C=C3)C(C)(C)C
Molecular Formula
C24H29FN6
Molecular Weight
420.53
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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