Radicicol
Product Specifications
CAS Number
12772-57-5
Target
Antifungal, Parasite, HSP, NOS, p38 MAPK, NF-κB, Antibacterial, Antibiotic
Related Pathways
Immunology/Inflammation, Cytoskeletal Signaling, NF-κB, Microbiology/Virology, MAPK, Metabolism
Bioactivity
Radicicol (Monorden) is an antifungal antibiotic and a potent inhibitor of heat shock protein 90 (Hsp90), which leads to the degradation of Hsp90 by the proteasome by binding to its ATP-binding pocket. In addition, Radicicol inhibits the growth and proliferation of several tumor cell lines. It also has anti-malarial activity and acts as an inhibitor of adipose- and obesity-related proteins (FTO) . Radicicol inhibits iNOS gene expression by blocking the p38 kinase signaling pathway and NF-kB/Rel
Smiles
C[C@@H]1C[C@@H]2[C@H](O2)/C=C\C=C\C(=O)CC3=C(C(=CC(=C3Cl)O)O)C(=O)O1
Molecular Formula
C18H17ClO6
Molecular Weight
364.78
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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