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Pyr6

Product Specifications

CAS Number

245747-08-4

Target

Calcium Channel, TRP/TRPV Channel

Related Pathways

Metabolism, Membrane transporter/Ion channel

Purity

0.9918

Bioactivity

Pyr6 (N-[4-[3,5-Bis (trifluoromethyl) -1H-pyrazol-1-yl]phenyl]-3-fluoro-4-pyridinecarboxamide) is a selective TRPC3 inhibitor with IC50 of 0.49 uM (Ca2+ influx inhibition in thapsigargin depleted native RBL-2H3 cells) .Pyr6 is an inhibitor of Ca2+ entry, which displays higher potency to inhibit Ca2+ entry mediated by CRAC channel than by TRPC3.

Smiles

Fc1cnccc1C(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F

Molecular Formula

C17H9F7N4O

Molecular Weight

418.27

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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