Pyr10
Product Specifications
CAS Number
1315323-00-2
Target
TRP/TRPV Channel
Related Pathways
Membrane transporter/Ion channel
Purity
0.997
Bioactivity
Pyr10 is a pyrazole derivative and a selective TRP cation 3 inhibitor that distinguishes between receptor-operated TRPC3 and native stromal interaction molecule 1 (STIM1) /Orai1 channels. Pyr10 inhibits Ca2+ influx in carbachol-stimulated TRPC3-transfected HEK293 cells (IC50: 0.72 μM) and has an IC50 of 13.08 μM for store-operated Ca2+ entry in BRL-2H3 cells.
Smiles
Cc1ccc(cc1)S(=O)(=O)Nc1ccc(cc1)-n1nc(cc1C(F)(F)F)C(F)(F)F
Molecular Formula
C18H13F6N3O2S
Molecular Weight
449.37
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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