PTC-028
Product Specifications
CAS Number
1782970-28-8
Target
Apoptosis, BMI-1
Related Pathways
DNA Damage/DNA Repair, Apoptosis, Cell Cycle/Checkpoint
Purity
0.9825
Bioactivity
PTC-028 selectively suppresses cancer cells whereas normal cells remain unaffected. PTC-028 is an orally bioavailable inhibitor of stem cell factor BMI-1 in ovarian cancer. The depletion of BMI-1 by PTC-028 causes caspase-mediated apoptosis.
Smiles
Cc1nc2cc(F)c(F)cc2n1-c1cncc(Nc2ccc(cc2)C(F)(F)F)n1
Molecular Formula
C19H12F5N5
Molecular Weight
405.32
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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