PS210
Product Specifications
CAS Number
1221962-86-2
Target
PDK
Related Pathways
PI3K/Akt/mTOR signaling
Purity
0.9978
Bioactivity
PS210 is a potent and selective activator of PDK1 (Kd: 3 ?M), specifically targeting the PIF-binding pocket of PDK1 without affecting other protein kinases such as S6K, PKB/Akt, or GSK3. Its prodrug, PS423, serves as a substrate-selective inhibitor of PDK1 in cells, inhibiting the phosphorylation and activation of S6K.
Smiles
OC(=O)C(C(CC(=O)c1ccc(cc1)C(F)(F)F)c1ccccc1)C(O)=O
Molecular Formula
C19H15F3O5
Molecular Weight
380.31
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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