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PROTAC Sirt2 Degrader-1

Product Specifications

CAS Number

2098487-75-1

Target

PROTACs|||Sirtuin

Related Pathways

DNA Damage/DNA Repair|||Chromatin/Epigenetic|||PROTAC

Bioactivity

PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC that acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 ?M for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 ?M) [1].

Smiles

Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(CCCCNC(=O)COc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)c3)s2)n1

Molecular Formula

C40H40N10O8S2

Molecular Weight

852.94

Shipping Conditions

Cool pack

Storage Temperature

-20°C

Available Sizes

Curated Selection

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