PROTAC Sirt2 Degrader-1
Product Specifications
CAS Number
2098487-75-1
Target
PROTACs, Sirtuin
Related Pathways
DNA Damage/DNA Repair, Chromatin/Epigenetic, PROTAC
Bioactivity
PROTAC Sirt2 Degrader-1 is a SirReal-based PROTAC that acts as a Sirt2 degrader, composed of a highly potent and isotype-selective Sirt2 inhibitor, a linker, and a bona fide cereblon ligand for E3 ubiquitin ligase. PROTAC Sirt2 Degrader-1 shows an IC50 of 0.25 μM for Sirt2, with no effect on Sirt1/Sirt3 (IC50s > 100 μM) [1].
Smiles
Cc1cc(C)nc(SCC(=O)Nc2ncc(Cc3cccc(OCc4cn(CCCCNC(=O)COc5cccc6C(=O)N(C7CCC(=O)NC7=O)C(=O)c56)nn4)c3)s2)n1
Molecular Formula
C40H40N10O8S2
Molecular Weight
852.94
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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