PRN694
Product Specifications
CAS Number
1575818-46-0
Target
Others, Tyrosine Kinases
Related Pathways
Tyrosine Kinase/Adaptors, Others
Bioactivity
PRN694 shows extended target residence time on ITK and RLK, enabling durable attenuation of effector cells in vitro and in vivo. PRN694 is an irreversible, highly selective, and effective covalent interleukin-2-inducible T-cell kinase (ITK) and resting lymphocyte kinase (RLK) dual inhibitor (IC50s: 0.3 nM and 1.4 nM, respectively) .
Smiles
C[C@H](NCc1ccc2n(C[C@H]3CCCN3C(=O)C=C)c(NC(=O)c3ccc(s3)C(F)F)nc2c1)C(C)(C)C
Molecular Formula
C28H35F2N5O2S
Molecular Weight
543.67
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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