Welcome to GenPrice! Check out our latest updates.

Shopping Cart (0)

Your cart is empty

Add some products to get started!

FTI-277 (hydrochloride)

FTI-277 hydrochloride is an inhibitor of farnesyl transferase (FTase) ; a highly potent Ras CAAX peptidomimetic which antagonizes both H- and K-Ras oncogenic signaling. FTI-277 hydrochloride can inhibit hepatitis delta virus (HDV) infection.

Product Specifications

CAS Number

180977-34-8

UNSPSC

12352005

Hazard Statement

H302, H410

Target

Apoptosis; Farnesyl Transferase; Ras

Type

Reference compound

Related Pathways

Apoptosis; GPCR/G Protein; MAPK/ERK Pathway; Metabolic Enzyme/Protease

Applications

Cancer-programmed cell death

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/FTI-277-hydrochloride.html

Purity

98.29

Solubility

DMSO : 100 mg/mL (ultrasonic) |H2O : 100 mg/mL (ultrasonic)

Smiles

CSCC[C@@H](C(OC)=O)NC(C1=CC=C(NC[C@@H](N)CS)C=C1C2=CC=CC=C2)=O.[H]Cl

Molecular Formula

C22H30ClN3O3S2

Molecular Weight

484.07

Precautions

H302, H410

References & Citations

[1]Cohen-Jonathan E, et al. The farnesyltransferase inhibitor FTI-277 suppresses the 24-kDa FGF2-induced radioresistance in HeLa cells expressing wild-type RAS. Radiat Res. 1999 Oct;152 (4) :404-11.|[2]Nakazawa H, et al. Role of protein farnesylation in burn-induced metabolic derangements and insulin resistance in mouse skeletal muscle. PLoS One. 2015 Jan 16;10 (1) :e0116633.|[3]Virtanen SS, et al. Inhibition of GGTase-I and FTase disrupts cytoskeletal organization of human PC-3 prostate cancer cells. Cell Biol Int. 2010 Aug;34 (8) :815-26.|[4]Bordier BB, et al. A prenylation inhibitor prevents production of infectious hepatitis delta virus particles. J Virol. 2002 Oct;76 (20) :10465-72.

Shipping Conditions

Room Temperature

Storage Conditions

4°C (Powder, sealed storage, away from moisture)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Citation 01

Adv Sci (Weinh) . 2024 Jun 18:e2307751.|FEBS Open Bio. 2025 Aug 8.|J Cell Mol Med. 2024 Dec;28 (24) :e70273.|Mol Cell Proteomics. 2023 Aug;22 (8) :100593.|Fish Shellfish Immunol. 2019 Apr 3;89:281-289.|Oncotarget. 2017 Nov 22;8 (65) :109135-109150.

Available Sizes

Frequently Asked Questions

More Discoveries

Explore Other Products

Browse additional items from our catalog

Il1b Rabbit Polyclonal Antibody
TA377442 100 µL

Il1b Rabbit Polyclonal Antibody

Sign In for Pricing
View Details
Mouse Ctla2a activation kit by CRISPRa
GA200943 1 Kit

Mouse Ctla2a activation kit by CRISPRa

Sign In for Pricing
View Details
Diethyl Adipate-d10
TRC-D455407-50MG 50 mg

Diethyl Adipate-d10

Sign In for Pricing
View Details
Tissue FFPE Sections, Lung
CS804328 5x 5 µm

Tissue FFPE Sections, Lung

Sign In for Pricing
View Details
2-Chloro-N,N-diethylethylamine Hydrochloride
TRC-C421850-1G 1 g

2-Chloro-N,N-diethylethylamine Hydrochloride

Sign In for Pricing
View Details
ZNF226 Mouse Monoclonal Antibody [Clone ID: OTI4E1]
CF812738 100 µg

ZNF226 Mouse Monoclonal Antibody [Clone ID: OTI4E1]

Sign In for Pricing
View Details