Phenoxodiol
Product Specifications
CAS Number
81267-65-4
Target
Apoptosis, Caspase, p53, Topoisomerase, IAP
Related Pathways
Proteases/Proteasome, Apoptosis, DNA Damage/DNA Repair
Purity
0.9918
Bioactivity
Phenoxodiol (Idronoxil) activates the mitochondrial caspase system, inhibits X-linked inhibitor of apoptosis (XIAP), disrupts FLICE inhibitory protein (FLIP) expression, and sensitizes the cancer cells to Fas-mediated apoptosis. Phenoxodiol induces cell cycle arrest in the G1/S phase of the cell cycle and upregulates p21WAF1 via a p53 independent manner. Phenoxodiol also inhibits DNA topoisomerase II.
Smiles
Oc1ccc(cc1)C1=Cc2ccc(O)cc2OC1
Molecular Formula
C15H12O3
Molecular Weight
240.25
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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