PG01
Product Specifications
CAS Number
853138-65-5
Target
CFTR
Related Pathways
Membrane transporter/Ion channel
Purity
0.9987
Bioactivity
PG01 is a potent CFTR Cl-channel potentiator, effective against ΔF508 (Ka 0.3 μM), and also against E193K, G970R and G551D (CFTR mutants), with Kd values of 0.22 μM, 0.45 μM and 1.94 μM, respectively.PG01 increases ΔF508-CFTR Cl- currents upon addition of forskolin. F508-CFTR Cl-current upon addition of Forskolin, correcting the gating defect of CFTR mutants.
Smiles
CC(C)c1ccc(NC(=O)C(N(C)C(=O)Cc2c[nH]c3ccccc23)c2ccccc2)cc1
Molecular Formula
C28H29N3O2
Molecular Weight
439.55
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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