PF-5006739
Product Specifications
CAS Number
1293395-67-1
Target
Casein Kinase
Related Pathways
Stem Cells|||Metabolism
Bioactivity
PF-5006739 is an effective and selective inhibitor of CK1?/? (IC50s: 3.9 nM and 17.0 nM, respectively) . PF-5006739 is a potential therapeutic agent for a range of psychiatric disorders with low nanomolar in vitro potency for CK1?/? and high kinome selectivity. PF-5006739 improves glucose tolerance in both diet-induced obesity (DIO) and genetic (ob/ob) mice models of obesity. PF-5006739 decreases opioid drug-seeking behavior in a rodent operant reinstatement model in animals in a dose-dependent manner.
Smiles
Nc1nccc(n1)-c1c(ncn1C1CCN(Cc2ccon2)CC1)-c1ccc(F)cc1
Molecular Formula
C22H22FN7O
Molecular Weight
419.45
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Curated Selection
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