PF-06465469
Product Specifications
CAS Number
1407966-77-1
Target
CXCR|||BTK|||PD-1/PD-L1|||Tyrosine Kinases|||LAG-3
Related Pathways
Autophagy|||Cell Cycle/Checkpoint|||Immunology/Inflammation|||Tyrosine Kinase/Adaptors|||Apoptosis|||GPCR/G Protein|||Angiogenesis
Bioactivity
PF-06465469 is a covalent ITK inhibitor (IC?? = 2 nM) that also inhibits BTK. PF-06465469 suppresses CXCL12-mediated cell migration, decreases PD-1 and LAG-3 expression. PF-06465469 shows strong potential application in leukemia and T-cell lymphoma research.
Smiles
NC1=C2C(=NN(C2=NC=N1)[C@H]3CN(C(C=C)=O)CCC3)C4=CC(C(NC5=CC(C)=C(C(C)C)C=C5)=O)=CC=C4
Molecular Formula
C30H33N7O2
Molecular Weight
523.63
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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