PF-06380101
Product Specifications
CAS Number
1436391-86-4
Target
Microtubule Associated|||ADC Cytotoxin
Related Pathways
Antibody-drug Conjugate/ADC Related|||Cytoskeletal Signaling
Bioactivity
PF-06380101 is an auristatin microtubule inhibitor and is a cytotoxic Dolastatin 10 analogue. When compared to other synthetic auristatin analogues that are used in the preparation of ADCs, PF-06380101 displays excellent potencies in tumor cell proliferation assays and differential ADME properties.
Smiles
CC[C@H](C)[C@@H]([C@@H](CC(=O)N1CCC[C@H]1[C@H](OC)[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)c1nccs1)OC)N(C)C(=O)[C@@H](NC(=O)C(C)(C)N)C(C)C
Molecular Formula
C39H62N6O6S
Molecular Weight
743.01
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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