Darigabat
Product Specifications
CAS Number
1614245-70-3
Target
GABA Receptor
Related Pathways
Membrane transporter/Ion channel, Neuroscience
Purity
0.9929
Bioactivity
Darigabat (PF-06372865) is an orally active and selective GABAA receptor modulator that crosses the blood-brain barrier and exhibits anxiolytic activity, with Ki values of 2.9 nM, 21 nM, and 134 nM for α2, α1 PAM, and α2 PAM, respectively.Darigabat is used in the study of anxiety disorders and epilepsy.
Smiles
CCn1cnc2c(cnnc12)-c1ccc(F)c(c1)-c1ccc(cc1OC)S(=O)(=O)CC
Molecular Formula
C22H21FN4O3S
Molecular Weight
440.49
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
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