PF-04995274
Product Specifications
CAS Number
1331782-27-4
Target
5-HT Receptor
Related Pathways
Neuroscience, GPCR/G Protein
Purity
0.9955
Bioactivity
PF-04995274 is an effective, high-affinity, and partial serotonin 4 receptor (5-HT4R) agonist. PF-04995274 is brain penetrant and can be used for cognitive disorders associated with Alzheimer's disease. PF-04995274 has an EC50 range of 0.26-0.47 nM for human 5-HT4A/4B/4D/4E (Ki range of 0.15-0.46 nM) . It also has an EC50 range of 0.59-0.65 nM for rat 5-HT4S/4L/4E (Ki of 0.30 nM for rat 5-HT4S) .
Smiles
OC1(CN2CCC(COc3noc4cccc(O[C@@H]5CCOC5)c34)CC2)CCOCC1
Molecular Formula
C23H32N2O6
Molecular Weight
432.51
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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