PF-03715455
Product Specifications
CAS Number
1056164-52-3
Target
P38 MAPK
Related Pathways
MAPK
Bioactivity
PF-03715455 potently inhibits LPS-induced TNFα production in human whole blood (IC50=1.7 nM) . PF-03715455 is an effective inhibitor of inhaled p38 MAPK. PF-03715455 displays some selectivity for p38α over p38β (respective IC50: 0.88 and 23 nM) . PF-03715455 has the potential for the treatment of COPD.
Smiles
S(C1=CN2C(=NN=C2C=C1)C3=C(SCCO)C=CC=C3)C4=C(CNC(NC=5N(N=C(C(C)(C)C)C5)C6=CC(Cl)=C(O)C=C6)=O)C=CC=C4
Molecular Formula
C35H34ClN7O3S2
Molecular Weight
700.27
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
Frequently Asked Questions
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