PAT-048
Product Specifications
CAS Number
1359983-15-5
Target
PDE
Related Pathways
Metabolism
Bioactivity
PAT-048 is an effective and selective autotaxin inhibitor. PAT-048 reduces dermal fibrosis in vivo. PAT-048 also inhibits IL-6 mRNA expression but displays no effect on autotaxin protein and pulmonary lysophosphatidic acid (LPA) production in the lung fibrosis model. PAT-048 has an IC50 and IC90 of 20 nM and 200 nM for autotaxin in mouse plasma.
Smiles
CC=1N(C=2C(C1SC3=C(F)C(C(O)=O)=CC=C3)=CC=C(Cl)C2F)C4=CN(CCC)N=C4
Molecular Formula
C22H18ClF2N3O2S
Molecular Weight
461.91
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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