NVP-2
Product Specifications
CAS Number
1263373-43-8
Target
Apoptosis|||CDK
Related Pathways
Apoptosis|||Cell Cycle/Checkpoint
Purity
0.9976
Bioactivity
NVP-2 is an effective and selective ATP-competitive cyclin-dependent kinase 9 (CDK9) probe. NVP-2 induces cell apoptosis. NVP-2 inhibits CDK9/CycT activity (IC50: 0.514 nM) . NVP-2 shows inhibitory effcts on CDK1/CycB, CDK2/CycA and CDK16/CycY kinases (IC50: 0.584 ?M, 0.706 ?M, and 0.605 ?M, respectively) .
Smiles
COC[C@@H](C)N[C@H]1CC[C@@H](CC1)Nc1cc(c(Cl)cn1)-c1cccc(NCC2(CCOCC2)C#N)n1
Molecular Formula
C27H37ClN6O2
Molecular Weight
513.07
Shipping Conditions
Cool pack
Storage Temperature
-20°C
Available Sizes
Curated Selection
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