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NU6140

Product Specifications

CAS Number

444723-13-1

Target

CDK, Aurora Kinase

Related Pathways

Chromatin/Epigenetic, Cell Cycle/Checkpoint

Purity

0.9833

Bioactivity

NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM) . It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively) . It also enhances the apoptotic effect and has anti-cancer activity.

Smiles

CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1

Molecular Formula

C23H30N6O2

Molecular Weight

422.52

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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