NU6140
Product Specifications
CAS Number
444723-13-1
Target
CDK, Aurora Kinase
Related Pathways
Chromatin/Epigenetic, Cell Cycle/Checkpoint
Purity
0.9833
Bioactivity
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM) . It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively) . It also enhances the apoptotic effect and has anti-cancer activity.
Smiles
CCN(CC)C(=O)c1ccc(Nc2nc(OCC3CCCCC3)c3[nH]cnc3n2)cc1
Molecular Formula
C23H30N6O2
Molecular Weight
422.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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