Pregnenolone acetate
Pregnenolone acetate (compound #43), a nonmetabolized Pregnenolone (HY-B0151) analog, can promote neurite extension and induce a change in growth cone morphology in primary cultures of cerebellar granule neurons. Pregnenolone acetate, a neurosteroid, increases microtubule polymerization. Pregnenolone acetate has the potential for neurodevelopmental diseases research[1].
Product Specifications
CAS Number
[1778-02-5]
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Microtubule/Tubulin
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/pregnenolone-acetate.html
Purity
98.40
Solubility
DMSO : 8 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C[C@@]12[C@](CC[C@@H]2C(C)=O)([H])[C@@]3([H])[C@]([C@@]4(C(C[C@H](CC4)OC(C)=O)=CC3)C)([H])CC1
Molecular Formula
C23H34O3
Molecular Weight
358.51
Precautions
H302, H315, H319, H335
References & Citations
[1]Viktoryia Kolas, et al. A synthetic pregnenolone analog promotes microtubule dynamics and neural development. Cell Biosci. 2022 Dec 1;12 (1) :190.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
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Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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