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Nitroaspirin

Product Specifications

CAS Number

175033-36-0

Target

COX, Apoptosis

Related Pathways

Immunology/Inflammation, Apoptosis, Neuroscience

Purity

0.9932

Bioactivity

Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin that inhibits cyclooxygenase. It induces cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells by down-regulating EGFR/PI3K/STAT3 signaling and modulating Bcl-2 family proteins. Additionally, Nitroaspirin possesses antithrombotic and antiplatelet properties and acts as a direct and irreversible inhibitor of COX-1.

Smiles

O(C(C)=O)C1=C(C(OC2=CC(CON(=O)=O)=CC=C2)=O)C=CC=C1

Molecular Formula

C16H13NO7

Molecular Weight

331.28

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

Available Sizes

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