Nitroaspirin
Product Specifications
CAS Number
175033-36-0
Target
COX, Apoptosis
Related Pathways
Immunology/Inflammation, Apoptosis, Neuroscience
Purity
0.9932
Bioactivity
Nitroaspirin (NCX 4016) is a nitric oxide donor and a nitro-derivative of Aspirin that inhibits cyclooxygenase. It induces cell cycle arrest and apoptosis in Cisplatin-resistant human ovarian cancer cells by down-regulating EGFR/PI3K/STAT3 signaling and modulating Bcl-2 family proteins. Additionally, Nitroaspirin possesses antithrombotic and antiplatelet properties and acts as a direct and irreversible inhibitor of COX-1.
Smiles
O(C(C)=O)C1=C(C(OC2=CC(CON(=O)=O)=CC=C2)=O)C=CC=C1
Molecular Formula
C16H13NO7
Molecular Weight
331.28
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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