Nigericin
Product Specifications
CAS Number
28380-24-7
Target
Sodium Channel, Apoptosis, NOD-like Receptor (NLR), Caspase, Pyroptosis, Potassium Channel, Antibiotic, Wnt/beta-catenin, Antibacterial
Related Pathways
Apoptosis, Stem Cells, Proteases/Proteasome, Cytoskeletal Signaling, Microbiology/Virology, Membrane transporter/Ion channel, Immunology/Inflammation
Purity
0.985
Bioactivity
Nigericin is a polyether antibiotic with potent antimicrobial, antimalarial, anticoronaviral and anticancer activities. It is capable of promoting cellular potassium efflux, inducing Caspase-1/GSDMD and Caspase-3-mediated cellular pyroptosis and apoptosis in triple-negative breast cancer, and inducing apoptosis in PEL (primary exudative lymphoma) cells through mitochondrial dysfunction and Wnt/β-catenin signaling downregulation.
Smiles
C[C@H]1[C@]2(O[C@@](C)(C1)[C@@]3(O[C@@](C)(CC3)[C@@]4(O[C@](C[C@@H]4C)([C@]5(O[C@](CO)(O)[C@H](C)C[C@@H]5C)[H])[H])[H])[H])O[C@H](C[C@@H]6O[C@@]([C@H](C(O)=O)C)([C@@H](C)CC6)[H])C[C@@H](OC)[C@H]2C
Molecular Formula
C40H68O11
Molecular Weight
724.96
Shipping Conditions
Ice Packs
Storage Temperature
-20°C
Available Sizes
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